Zena Werb Selected Research

Matrix Metalloproteinase Inhibitors

5/2015	Matrix metalloproteinases in stem cell regulation and cancer.
1/2014	Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs.
3/2010	Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression.
12/2006	Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.
6/2006	Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.
4/2006	Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease.
3/2003	Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases.

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Zena Werb Research Topics

Disease

57	Neoplasms (Cancer) 01/2022 - 03/2002
23	Breast Neoplasms (Breast Cancer) 01/2021 - 11/2005
14	Neoplasm Metastasis (Metastasis) 01/2021 - 03/2002
13	Inflammation (Inflammations) 01/2021 - 04/2002
12	Carcinoma (Carcinomatosis) 10/2018 - 06/2005
10	Carcinogenesis 12/2019 - 11/2002
6	Fibrosis (Cirrhosis) 01/2018 - 04/2006
4	Spinal Cord Injuries (Spinal Cord Injury) 01/2014 - 09/2002
3	Wounds and Injuries (Trauma) 04/2010 - 02/2006
2	Hypoxia (Hypoxemia) 01/2018 - 09/2008
2	Triple Negative Breast Neoplasms 12/2016 - 11/2016
2	Disease Progression 12/2014 - 04/2006
2	Proteinuria 07/2013 - 04/2006
2	Lung Injury 07/2012 - 12/2009
2	Bullous Pemphigoid (Pemphigoid) 10/2011 - 04/2005
2	Infections 06/2011 - 01/2005
2	Gliosis 12/2008 - 09/2003
2	Asthma (Bronchial Asthma) 11/2006 - 04/2002
2	Pathologic Neovascularization 02/2005 - 06/2003
2	Choroidal Neovascularization 12/2003 - 10/2002
2	Macular Degeneration (Age-Related Maculopathy) 12/2003 - 10/2002
1	Noninfiltrating Intraductal Carcinoma (DCIS) 06/2020
1	Neoplasm Micrometastasis 01/2020
1	Circulating Neoplastic Cells 12/2019
1	Nervous System Diseases (Neurological Disorders) 01/2017
1	Retinoblastoma (Glioblastoma, Retinal) 03/2016

Drug/Important Bio-Agent (IBA)

24	Matrix Metalloproteinases (MMPs)IBA 05/2015 - 03/2002
12	Matrix Metalloproteinase 9 (Gelatinase B)IBA 12/2019 - 09/2002
11	Phenobarbital (Luminal)FDA Link 01/2020 - 12/2003
9	EnzymesIBA 01/2021 - 07/2005
8	CollagenIBA 01/2021 - 11/2002
7	Biological ProductsIBA 10/2018 - 11/2002
7	Matrix Metalloproteinase InhibitorsIBA 05/2015 - 03/2003
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2005
6	Peptide Hydrolases (Proteases)FDA Link 04/2010 - 09/2002
5	Transcription Factors (Transcription Factor)IBA 11/2016 - 07/2005
5	Tumor Viral Antigens (Large T Antigen)IBA 11/2014 - 12/2003
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2013 - 12/2003
5	ChemokinesIBA 12/2012 - 12/2002
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 07/2012
4	Matrix Metalloproteinase 2 (Gelatinase A)IBA 12/2006 - 04/2002
3	Phosphotransferases (Kinase)IBA 11/2016 - 12/2003
3	Metalloproteases (Metalloproteinases)IBA 01/2016 - 03/2003
3	AntibodiesIBA 10/2014 - 04/2005
3	N- (2(R)- 2- (hydroxamidocarbonylmethyl)- 4- methylpentanoyl)- L- tryptophan methylamideIBA 01/2014 - 06/2006
3	Indicators and Reagents (Reagents)IBA 07/2012 - 11/2006
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2012 - 02/2005
3	Messenger RNA (mRNA)IBA 08/2008 - 11/2005
2	RNA (Ribonucleic Acid)IBA 01/2020 - 02/2018
2	GelatinasesIBA 12/2019 - 09/2003
2	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 10/2018 - 04/2005
2	Chemokine CXCL12IBA 01/2018 - 06/2005
2	Estrogen ReceptorsIBA 11/2016 - 04/2008
2	Hormones (Hormone)IBA 11/2016 - 10/2014
2	Pharmaceutical PreparationsIBA 05/2015 - 04/2012
2	MicroRNAs (MicroRNA)IBA 10/2013 - 12/2012
2	Cadherins (E-Cadherin)IBA 09/2012 - 03/2011
2	Glycoproteins (Glycoprotein)IBA 07/2012 - 12/2009
2	EndopeptidasesIBA 04/2011 - 10/2004
2	prinomastat (Ag3340)IBA 03/2010 - 03/2004
2	Epidermal Growth Factor (EGF)IBA 12/2009 - 12/2006
2	DNA (Deoxyribonucleic Acid)IBA 06/2009 - 07/2005
2	PlasminogenIBA 05/2009 - 04/2005
2	Chondroitin Sulfate ProteoglycansIBA 12/2008 - 09/2006
2	Integrin beta1IBA 10/2007 - 05/2007
2	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 12/2006 - 06/2006
2	Conditioned Culture MediaIBA 01/2006 - 11/2005
2	Heparitin Sulfate (Heparan Sulfate)IBA 11/2005 - 11/2005
2	IntegrinsIBA 06/2003 - 09/2002
1	ProdrugsIBA 01/2021
1	AldehydesIBA 01/2021
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2021
1	2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine (Lysyl Hydroxylase)IBA 01/2021
1	HydroxylysineIBA 01/2021
1	Monoclonal AntibodiesIBA 12/2019
1	AcPhe(ornithine- Pro- cyclohexylamine- Trp- Arg)IBA 10/2018
1	Complement System Proteins (Complement)IBA 10/2018
1	Complement C5a (Complement 5a)IBA 10/2018
1	Paclitaxel (Taxol)FDA LinkGeneric 10/2018
1	Peptides (Polypeptides)IBA 10/2018
1	CXCR4 Receptors (CXCR4 Receptor)IBA 01/2018
1	Discoidin Domain Receptor 1IBA 01/2018
1	Proline (L-Proline)FDA Link 01/2017
1	Basic Helix-Loop-Helix Transcription FactorsIBA 01/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2016
1	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2016
1	LigandsIBA 12/2016
1	pirfenidoneIBA 12/2016
1	Progesterone Receptors (Progesterone Receptor)IBA 11/2016
1	Polychlorinated Biphenyls (PCBs)IBA 03/2016
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 03/2016
1	rac1 GTP-Binding ProteinIBA 03/2016
1	Estradiol (Delestrogen)FDA LinkGeneric 03/2016
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 02/2015
1	AntigensIBA 11/2014

Therapy/Procedure

20	Therapeutics 01/2021 - 10/2002
4	Drug Therapy (Chemotherapy) 10/2018 - 09/2002
2	Transplantation 12/2015 - 10/2015
2	Lasers (Laser) 12/2003 - 10/2002
1	Immunotherapy 10/2018